>> SYDNEY LINE - section: MEDICAL 5/6 <<
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Group 4: syndromes with an abnormality on a specific gene.
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Important examples of group 4 syndromes are:
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1 – De Lange syndrome (gene: unknown).
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2 – Rubinstein-Taybi syndrome (gene: 16p13.3).
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3 – Williams-Beuren syndrome (gene: 7q11.23).
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4 – Smith-Lemi-Opitz syndrome (gene: 7q32.1)
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5 – Prader-Willi syndrome (gene: 15q11-q13).
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6 – Soto syndrome (gene: unkown).
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7 – Russell-Silver syndrome (gene: unknown).
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The scientific literature presents 'phantom pictures' for: De Lange syndrome, Rubinstein-Taybi syndrome, and Williams-Beuren syndrome.
DERMATOGLYPHIC RESEARCH ON THE ETIOLOGY OF DISEASES
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In the first paragraph of this course was described that nowadays dermatoglyphic research is merely focussed on studying the etiology of complex diseases and syndromes.
The etiology of many diseases is influenced by a large number of genes combined with environmental influences.
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Regarding the environmental influences one can discriminate teratogen influences from exogen influences:
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Teratogen influences start being manifest during pregnancy.
Examples of teratogen influences are: (high) age of the mother, food, stress, (infection) diseases, medicine, drugs, chemicals, and
radiation danger.
During the first 4 months of pregnancy the effect of teratogen influences can be very disturbing.
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Figure B-6: the Sydney line - the long head line ends near
the ulnar side of the palm (the side of the little finger).
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