Multi-perspective hand reading!

Scientific Hand Charts Collection:
Cornelia de Lange syndrome!


Publication: december 12, 2015

3 Hand Charts for Cornelia de Lange syndrome!

Cornelia de Lange syndrome - often termed Bushy Syndrome or Amsterdam dwarfism - is a very rare genetic disorder present from birth, but not always diagnosed at birth; it causes a range of physical, cognitive and medical challenges and affects both genders.

Prevalence: estimated at 1 in 15,000 live births.

Quite a few detailed hand charts are available for Cornelia de Lange syndrome; most charts describe the significance of various typical features inside especially the dermatoglyphics, which manifest often combined with a simian line (= single transverse flexion crease) and/or a single interphalangeal crease on the pinky finger.


NOTICE: Individual hand features described below should not get associated in isolation with any theme; only combinations involving multiple hand levels have potential for diagnostic purposes.

Hand chart for Cornelia de Lange syndrome (1981).
Hand chart source:
Hautleistenfibel (1981), p.112;
authors: A. Rodewald & H. Zankl

Hand chart for Cornelia de Lange syndrome - Dermatoglyphics in Medical Disorders (1976).
Hand chart source:
Dermatoglyphics in Medical Disorders (1976), p.197;
authors: B. Schaumann & M. Alter

Hand chart for Cornelia de Lange syndrome - Handbook of Clinical Dermatoglyphics (1971).
Hand chart source:
Handbook of Clinical Dermatoglyphs (1971), p.45;
authors: M.S. Elbualy & J.D. Schindeler

Other significant hand signs (not reported inside the hand charts):

In most infants with Cornelia de Lange syndrome, the hands show various mild defects such as: small hands for their size [micromelia]; the thumbs may be abnormally positioned - i.e. proximally placed; in addition, affected individuals may have short fingers that become smaller and thinner toward the ends (tapered fingers), fifth fingers that are permanently curved toward the ring finger (clinodactyly), and/or, in up to 30% absence of one or more fingers [oligodactyly] - see first picture below (source: NORD).

Hypoplasia of the medial phalanx of the fifth finger (or 2nd finger) and hypoplasia of the first metacarpal (resulting in a short, thick bone) is very specific for CdLS, and affects 90% of postnatally evaluated patients [Braddock et al., 1993].

A high proportion of the infants also has one or more structural defects; a summary of the most common variations has been described in the article Characterization of Limb Differences in Children With Cornelia de Lange Syndrome (2016).

Delayed motor development is also a typical feature - though fine motor skills are developed relatively well (source: Medscape).

Range of hand abnormalities in Cornelia de Lange syndrome.
Range of hand abnormalities in Cornelia de Lange syndrome.

Cornelia de Lange syndrome hands.
Cornelia de Lange syndrome hands
(source: European Journal of Medical Genetics).

All significant hand signs listed above for Cornelia de Lange syndrome together cover four out of the nine perspectives of the hand as defined according Multi-Perspective Hand Reading (including hand level 2, 5, 8 & 9).

A summary of the most significant hand sign combinations in Cornelia de Lange syndrome is described here:

Decoding the language of the hand:
hand sign combinations in Cornelia de Lange syndrome!

Hand charts are available for many other diagnostic issues;
start browsing HERE

SCIENTIFIC HAND CHARTS: Introduction

Hand charts for Big Five personality dimensions:
Hand chart(s) for Agreeableness (2x: 1 in 4 people)
Hand chart(s) for Conscientiousness (2x: 1 in 4 people)
Hand chart(s) for Extraversion (2x: 1 in 4 people)
Hand chart(s) Neuroticism (2x: 1 in 4 people)
Hand chart(s) Openness (2x: 1 in 4 people)

Hand charts for diseases:
Hand charts for hypercalcemia (1 in 4,000 people)

Hand charts for syndromes:
Hand charts for arthrogryposis (1 in 10,000 people)
Hand charts for cri-du-chat syndrome (1 in 30,000 people)
Hand charts for Down syndrome (1 in 700 live births)
Hand charts for Edwards syndrome (1 in 6,000 live births)
• Hand charts for fetal alcolhol syndrome (1 in 500 people)
Hand charts for fragile-X syndrome (1 in 5,000 people)
Hand charts for Holt-Oram syndrome (1 in 100,000 live b.)
Hand charts for Kabuki syndrome (1 in 32,000 people)
Hand charts for Klinefelter syndrome (1 in 1000 males)
Hand charts for de Lange syndrome (1 in 15,000 live births)
• Hand charts for Marfan syndrome (1 in 5,000 people)
Hand charts for Patau syndrome (1 in 15,000 live births)
Hand charts for Prader-Willi syndrome (1 in 15,000 births)
Hand charts for Rubella syndrome (1 in 100,000 people)
• Hand charts for Rubinstein syndrome (1 in 200,000 births)
Hand charts for SLOS (1 in 40,000 births)
Hand charts for Turner syndrome (1 in 2,000 female births)
• Hand charts for Warkany syndrome (1 in 200,000 births)
Hand charts for Williams syndrome (1 in 14,000 births)
Hand charts for Wolf-Hirschhorn syndrome (1 in 50,000 b.)
Hand charts for XXYY syndrome (1 in 30,000 male births)
Hand charts for XYY syndrome (1 in 1,000 male births)
Hand charts for 18 deletion syndromes (2 in 40,000 live b.)

NOTICE: Reflexology hand charts are not included in this section because the scientific foundation of any of such charts is actually unknown; nevertheless, you can read more about the fundamentals of such charts HERE.
Structure of a DNA polymerase for the hand, including: palm, fingers & thumb.
Other charts & maps:
Fingerprints world map
Hand reading experts world map
Hand reflexology charts


HAND CHARTS MENU:

Hand chart for the Big Five personality dimension Agreeableness (2017) Hand chart for the Big Five personality dimension Conscientiousness (2017) Hand chart for the Big Five personality dimension Extraversion (2017) Hand chart for the Big Five personality dimension Neuroticism (2017) Hand chart for the Big Five personality dimension Openness (2017) Hand chart for hypercalcemia (1971) Hand chart for arthrogryposis (1981) Hand chart for cri-du-chat syndrome - Hautleistenfibel (1981) Hand chart for Down syndrome (2011) Hand chart for Edwards syndrome (1981) Hand chart for fragile-X syndrome (2014) Hand chart for Holt-Oram syndrome (1981) Hand chart for Kabuki syndrome (Albert, 1999) Hand chart for Klinefelter syndrome (A. Rodewald & H. Zankl, 1981) Hand chart for Cornelia de Lange syndrome (A. Rodewald & H. Zankl, 1981) Hand chart for Patau syndrome (1981) Hand chart for Prader-Willi syndrome (1971) Hand chart for rubella syndrome (1971) Hand chart for Smith-Lemli-Opitz syndrome (1971) Hand chart for Turner syndrome - Hautleistenfibel (1981) Hand chart for Williams syndrome (R. Rodewald, 1994) Hand chart for Wolf-Hirschhorn syndrome (B. Schaumann & M. Alter, 1976) Hand chart for XXYY syndrome (1971) Hand chart for XYY syndrome (1971) Hand chart for 18p- syndrome, a.ka. de Grouchy syndrome 1 (1981)