Hand chart for the Big Five personality dimension Conscientiousness (2016) Hand chart for the Big Five personality dimension Extraversion (2016) Hand chart for the Big Five personality dimension Neuroticism (2016) Hand chart for hypercalcemia (1971) Hand chart for arthrogryposis (1981) Hand chart for cri-du-chat syndrome - Hautleistenfibel (1981) Hand chart for Down syndrome (2011) Hand chart for Edwards syndrome (1981) Hand chart for fragile-X syndrome (2014) Hand chart for Holt-Oram syndrome (1981) Hand chart for Kabuki syndrome (A. Chudley) Hand chart for Klinefelter syndrome (A. Rodewald & H. Zankl, 1981) Hand chart for Cornelia de Lange syndrome (A. Rodewald & H. Zankl, 1981) Hand chart for Patau syndrome (1981) Hand chart for Prader-Willi syndrome (1971) Hand chart for rubella syndrome (1971) Hand chart for Smith-Lemli-Opitz syndrome (1971) Hand chart for Turner syndrome - Hautleistenfibel (1981) Hand chart for Williams syndrome (R. Rodewald, 1994) Hand chart for Wolf-Hirschhorn syndrome (B. Schaumann & M. Alter, 1976) Hand chart for XXYY syndrome (1971) Hand chart for XYY syndrome (1971) Hand chart for 18p- syndrome, a.ka. de Grouchy syndrome 1 (1981)

- Some of the available hand charts are displayed above - you can use the displayed pictures above for browsing -


Publication: november 21, 2015

Hand Charts for Smith-Lemli-Opitz syndrome!

Smith-Lemli-Opitz syndrome - a.k.a. SLOS, or 7-dehydrocholesterol reductase deficiency - is an inborn error of cholesterol synthesis caused by a mutation in the enzyme 7-Dehydrocholesterol reductase, or DHCR7. It causes a broad spectrum of effects, ranging from mild intellectual disability and behavioural problems to lethal malformations.

Prevalence: described to be close to 1 in 40,000 births.

One rather superficial hand chart is available for Smith-Lemli-Opitz syndrome describing only 3 characteristics in the dermatoglyphics, involving: 1) increased whorls producing a high ridge count, 2) simian crease - see picture below.


NOTICE: Individual hand features described below should not get associated in isolation with any theme; only combinations involving multiple hand levels have potential for diagnostic purposes.

Hand chart for Smith-Lemli-Opitz syndrome - Handbook of Clinical Dermatoglyphs (1971).
Hand chart source:
Handbook of Clinical Dermatoglyphs (1971), p.51;
authors: M.S. Elbualy & J.D. Schindeler




Other significant hand signs (not reported inside the hand charts):

Various sources have reported that the characteristic fingerprint pattern in SLOS typically manifests in a reduced occurence of ulnar loops; therefore, next to a high occurence of whorls, a high occurence of arches is also possible (producing a low ridge count). A high prevalence of a distal axial triradius (t") and/or a thenar/ID1 pattern are also common (source: B. Scheimann & M. Alter, 1976).

Hand related behavior characteristics typical for Smith-Lemli-Opitz syndrome are hand biting & hand flapping/flicking; marked tactile hypersensitivity of the hands and feet is also seen in more than 50% of patients (source: Journal of Medical Genetics, 2000).

Short, flexed fingers [clenched hand] are ocasionally also present (source: J.X. Scott, 2004).

A short, proximally placed thumb may also be present; polydactyly/extra fingers on the ulnar/post-axial side of the hand - see picture below - is also often present (source: Wikipedia).

Baby hand involving Smith-Lemli-Opitz syndrome: post-axial polydactyly.
Baby hand involving Smith-Lemli-Opitz syndrome: post-axial polydactyly.


All significant hand signs listed above for Smith-Lemli-Opitz syndrome together cover five out of the nine perspectives of the hand as defined according Multi-Perspective Hand Reading (including hand level 1, 5, 6, 8 & 9).

A summary of the most significant hand sign combinations in Smith-Lemli-Opitz syndrome is described here:

Decoding the language of the hand:
hand sign combinations in Smith-Lemli-Opitz syndrome!





Hand charts are available for many other diagnostic issues;
start browsing HERE


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