1 - PALMAR SKIN CONDITIONS & CANCERS: 'Tripe palms' relate to lung cancer & stomach cancer: Tripe palms describes a skin condition in which the skin of the palm becomes thick and velvety-white with pronounced folds in the lines of the hand. The skin resembles boiled tripe. It's a sign of cancer. If only the palms are involved, it's most likely lung cancer. If tripe palms is accompanied by acanthosis nigricans, the underlying malignancy is most commonly stomach (35%) or lung (11%) cancer. What are tripe palms? Tripe palms are characterised by thickened velvety palms that have the appearance of tripe, the stomach lining of beef, pork, or sheep. Approximately 90% of cases of tripe palms are associated with internal malignancy. This skin disease is very rare. It usually occurs before the diagnosis of the cancer, but may arise during any point in the course of the malignancy. In over 40% of patients, tripe palms are the first sign of an undiagnosed cancer, hence all patients should undergo a full diagnostic workup for an associated malignancy, particularly lung cancer, gastrointestinal carcinoma, or a colonic polyps. There is no specific treatment for tripe palms. It has been reported that approximately 30% of cases resolve once the underlying cancer is treated. However, tripe palms inconsistently respond to successful therapy and may persist for many years despite remission of the underlying cancer. Sources: Can palm reading pick up cancer? Tripe palms are a.k.a. ‘acanthosis palmaris’ What your skin says about your health Tripe palms is a common characteristic in lung & stomach cancer:

2 - HAND SHAPE CONDITIONS & CANCERS: 'Palmar fascial thickening' relates to ovarian cancer & various other cancers: Curling or thickening of the hand palm combined with swelling of the fingers, making the hand look like wood with lumpy areas. It's called PFPAS, a.k.a the 'palmar fasciitis and polyarthritis syndrome'. Combined with a deepening of the palmar lines this hand characteristic is since 1982 known as a signal for ovarian cancer - but it's a very rare condition for since then about 40 cases have been reported. Nevertheless, this palm condition has also been associated with colon cancer, pancreas cancer, lung cancer, cervix cancer and hematolymphatic malignancies. What are the 'palmar fascia'? The palmar fascia lie under the skin on the palm of the hand and fingers. These fascia are a thin sheet of connective tissue, and the fascia separate into thin bands of tissue at the fingers. The fascia cover the tendons of the palm of the hand and holds them in place. It also prevents the fingers from bending too far backward when pressure is placed against the front of the fingers. NOTICE: a common problem with the palmar fascia concerns 'Dupuytren's contracture': which is characterised by the forming of nodules and the thickening of tissues and shorten. 'Dupuytren's contracture' usually results in the bending of fingers until the finger cannot be fully straightened. PFPAS is a 'paraneoplastic syndrome' featured by pain of the hands. The basic characteristic of 'paraneoplastic syndromes' is that they are characterised by not being produced by the primary tumor itself, and also it is not caused by compression or treatment of the tumor. Sources: Doctor picked up ovarian cancer through palm reading! Palmar fasciitis and polyarthritis associated with ovarian carcinoma The palmar fasciitis and polyarthritis syndrome: discussion of diagnosis Palmar fascial thickening is a common characteristic in ovarian cancer:

3 - FINGERNAIL CONDITIONS & CANCERS: 'Fingernail clubbing' relates to lung cancer: One fingernail condition has been known since the early days of the Greek philosopher Hippocrates, who recognized a 'clubbing fingernail' as a sign of disease. Today is the 'Hippocratic fingernail' associated with various diseases, including: lung cancer + other lung diseases (heart problems and gastrointestinal problems may also included but are less common). How to recognize a 'clubbing fingernail'? Fingernail clubbing is characterized by increases in distal finger tip mass and increased longitudinal and horizontal curvature of the nail plate. In this fingernail condition the angle between the nail plate and the proximal nail fold is greater than 180o, whereas in normal nails the angle is less than 160o: see the picture on the right. NOTICE: Clubbing is usually a painless but complex fingernail disorder (5 stages are described by Schamroth's test), with 3 causal category types (congenital/hereditary, acquired and idiopathic) - which often goes unnoticed of it's presence in the hands of patients! Nail clubbing has been reported in 29% of patients with lung cancer and is observed more commonly in patients with non–small cell lung carcinoma (35%) than in patients with small cell lung carcinoma (4%). Sources: What is a clubbing nail? - Development, treatment & prevention! Clubbed fingernails in elderly patients! Fingernail clubbing: signs, symptoms & diagnosis Medscape: 'clubbing of the nail' Clubbing fingernails is a common characteristic in lung cancer: