Martijn van Mensvoort - © Hand Research

 



HAND RESEARCH

The hand in diabetes melitus.

- THE HANDS OF A DIABETIC -

HAND SIGNS & DIAGNOSTICS:

The hand in DOWN SYNDROME!
_- Down syndrome case study 1
_- Down syndrome case study 2

The hand in FRAGILE-X SYNDROME!
_- Fragile-X syndrome case study 1
_- Fragile-X syndrome case study 2
_(In people with autism 2% to 6% have Fragile-X syndrome!)

The hand in DIABETES MELLITUS!
The hand in RHEUMATOID ARTHRITIS!
The hand in PSORIASIS!
The hand in SCHIZOPHRENIA!


SIMIAN LINE INDEX:

INTRO: About the Simian Line (a.k.a. 'simian crease')

HOW TO RECOGNIZE a 'complete' Simian Line?
WHY PALM CREASE NAMED the Simian Line?
BRIEF HISTORY of the Simian Line
ETHNIC POPULATIONS & the Simian Line
MEDICAL PROBLEMS & the Simian Line
PSYCHOLOGY & the Simian Line
PROJECTS related to the Simian Line
SYNONYMS for the Simian Line
FAMOUS Simian Line holders

Video: fingernail problems in diabetes mellitus











MORE HAND DIAGNOSTICS:

The hand lines (palmar creases)
The Sydney line
Fingerprints (+ dermatoglyphics)
The Hypothenar whorl
The 5th finger (pinky)
The fingernail tutor

More news - hands on health care!

EARLY HAND DIAGNOSTICS:
& HANDS ON HEALTH CARE!!








THE TOP 10 HAND SIGNS
IN DIABETES MELLITUS TYPE 1:


(Ranked by 'Log Odds Ratio' = LOR)

I - Thick, waxy/hardening skin on back of hand (sclerodactyly)
[Diabetes hand sign 6-1: LOR = +4.58]

II - Fingerprints: radial loop on pinky
[Diabetes hand sign 5-2: LOR = +3.16]

III - Fingerprints: radial loop on ringfinger
[Diabetes hand sign 5-1: LOR = +3.09]

IV - Neuropathy: loss of function: movement / sensation (Tinel's sign, Phalen's test, preacher sign / prayer sign, limited joint mobility)
[Diabetes hand sign 7-1: LOR = +2.98]

V - Pink patches on back of the hand / fingers (granuloma annulare lesions)
[Diabetes hand sign 6-3: LOR = + 2.73]

VI - Shiny patches, first: red-brown & painless, later: yellow & ulceration (necrobiosis lipoidica)
[Diabetes hand sign 6-6: LOR = + 2.71]

VII - Little skin pebbles on back of the hand / fingers (Huntley's papules)
[Diabetes hand sign 6-4: LOR = + 2.64]

VIII - Locked finger, a.k.a. 'trigger finger' (stenosing tenosynovitis)
[Diabetes hand sign 7-3: LOR = +2.50]

IX - Palm: high density on thenar
[Diabetes hand sign 5-13: LOR = + 2.50]

X - Palm: radial arch on hypothenar
[Diabetes hand sign 5-11: LOR = + 2.47]


THE TOP 10 HAND SIGNS
IN DIABETES MELLITUS TYPE 2:


(Ranked by 'Log Odds Ratio' = LOR)

I - Neuropathy: loss of function: movement / sensation (Tinel's sign, Phalen's test, preacher sign / prayer sign, limited joint mobility)
[Diabetes hand sign 7-1: LOR = +3.36]

II - Fingerprints: radial loop on pinky
[Diabetes hand sign 5-2: LOR = +3.16]

III - Fingerprints: radial loop on ringfinger
[Diabetes hand sign 5-1: LOR = +3.09]

IV - Half white, half pink nails (Terry's nails)
[Diabetes hand sign 2-3: LOR = +3.09]

V - Pink patches on back of the hand / fingers (granuloma annulare lesions)
[Diabetes hand sign 6-3: LOR = + 2.73]

VI - Shiny patches, first: red-brown & painless, later: yellow & ulceration (necrobiosis lipoidica)
[Diabetes hand sign 6-6: LOR = + 2.71]

VII - Little skin pebbles on back of the hand / fingers (Huntley's papules)
[Diabetes hand sign 6-4: LOR = + 2.64]

VIII - Locked finger, a.k.a. 'trigger finger' (stenosing tenosynovitis)
[Diabetes hand sign 7-3: LOR = +2.50]

IX - Palm: radial arch on hypothenar
[Diabetes hand sign 5-11: LOR = + 2.28]

X - Simian line
[Diabetes hand sign 4-1: LOR = +2.24]


These TOP 10 hand signs for Diabetes Mellitus type 1 & 2 show that skin abnormalities (combined with motoric problems) play a key role in recognizing Diabetes Mellitus.


NOTICE: Log Odds Ratios are calculated from the prevalence (%) among Diabetes patients & controls; more details are presented in the right column at the bottom of this page.

 


- 34 Hand Signs in Diabetes Mellitus -

Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar. The result of many studies indicate that there is a large group of hand signs that can be described as 'typical' for diabetes mellitus type 1 & type 2: five hand signs have log odds ratio statistics above 15 for both types of diabetes.

The result of many studies indicate that certain skin abnormalities (often combined with motoric problems) are indicative for the metabolic problems related to diabetes!

34 Hand signs significant for Diabetes Mellitus
TOP 10 - Diabetes Mellitus type 1 & 2: the ten most significant hand signs!
How to make a hand-diagnosis for Diabetes Mellitus: 4 requirements!







Multi-perspective palm reading.

How to make a Palm Reading Assessment
for DIABETES MELLITUS (Type 1 & 2)

Key-elements of the hand in Diabetes Mellitus (type 1 & 2) in a nutshell: skin / nail problems and or motoric problems, palmar dermatoglyphic stereotypes below the ring finger & the hypothenar, high occurence of the simian crease.

Diabetes Mellitus.
Phantom picture for Diabetes Mellitus.

[Phantom picture for Diabetes Type 1 & 2 will be available later]


Studies have shown that there not much difference between recognizing diabetes mellitus type 1 and type 2 from the hand only. An advanced hand diagnosis for Diabetes Mellitus requires a person to have multiple significant hand markers that follow the MAJOR REQUIREMENT + the additional requirements described below:

MAJOR REQUIREMENT: The person requires to have significant hand markers for Diabetes Mellitus in at least three dimensions of the hand

- ADDITIONAL REQUIREMENT A: The person requires to have at least one hand marker that relates to one of the following three perspectives: FINGERNAILS (= hand perspective 2), or SKIN QUALITY (= hand perspective 6), or MOTORICS (= hand perspective 7)

- ADDITIONAL REQUIREMENT B: The person requires to have at least two hand markers that relates to DERMATOGLYPHICS (= hand perspective 5).

- ADDITIONAL REQUIREMENT C: The person requires to have at least one hand marker in the palm (or back of the hand) + at least one hand marker in the fingers.


(More specifications will follow soon)



IMPORTANT: Even when all above REQUIREMENTS are fullfilled, then one can still NOT speak of a 'confirmed' hand diagnosis for Diabetes Mellitus: an additional health assessment beyond the hand is still requirement!

Some of the 34 significant hand markers for Diabetes Mellitus that are listed below became known in medical science as a 'physical minor anomaly' (such as the simian crease & the Sydney line).
But in general most of these individual hand markers can usually be described as harmless body characteristics - except for the markers described for perspectives 2, 6 and 7.







- List of 34 hand markers for Diabetes Type 1 & 2 -


• Hand perspective 1 - HAND SHAPE:
- 1-1: Appearent hand shape asymmetry.

• Hand perspective 2 - FINGERNAILS:
- 2-1: Fungal infection of the nail (onychomycosis);
- 2-2: Redness in proximal nail fold (chronic paronychia);
- 2-3: Half white, half pink nails (Terry's nails);
- 2-4: Blue lunula;
- 2-5: Yellow nails + yellow skin;
- 2-6: Spoon nail (koilonychia).

• Hand perspective 3 - FINGER MORPHOLOGY:
- 3-1: High finger length asymmetry: e.g. 2D:4D asymmetry.

• Hand perspective 4 - MAJOR LINES:
- 4-1: Simian crease;
- 4-2: Sydney line.

• Hand perspective 5 - DERMATOGLYPHICS:
- 5-1: Fingers: radial loop on ringfinger;
- 5-2: Fingers: radial loop on pinky;
- 5-3: Fingers: high thumb minus pinky ridge count (high MD15);
- 5-4: Palm: triradius c below ring finger is missing;
- 5-5: Palm: ridge line C ends below ring finger (abbortive ridge line C);
- 5-6: Palm: a-b ridge count summarized for both hands < 70 (ridge count between triradius below index finger & triradius below middle finger);
- 5-7: Palm: 2 or 3 triradii on hypothenar;
- 5-8: Palm: high positioned axial triradius;
- 5-9: Palm: triradius t is missing;
- 5-10: Palm: ulnar loop on hypothenar;
- 5-11: Palm: radial arch on hypothenar;
- 5-12: Palm: pattern in the hypothenar OR thenar of just one hand;
- 5-13: Palm: high density on thenar.

• Hand perspective 6 - SKIN QUALITY:
- 6-1: Thick, waxy/thickening skin on back of the hand (sclerodactyly);
- 6-2: Infections;
- 6-3: Pink patches on back of the hand / fingers (granuloma annulare lesions);
- 6-4: Little skin pebbles on back of the hand / fingers (Huntley's papules);
- 6-5: Blisters (bullosis diabeticorum);
- 6-6: Shiny patches, first: red-brown & painless, later: yellow & ulceration (necrobiosis lipoidica);
- 6-7: Dramatic appearing hand infections (e.g. Tropical Diabetic Hand Syndrome).

• Hand perspective 7 - MOTORICS:
- 7-1: Neuropathy: loss of function, loss of movement / sensation (Tinel's sign, Phalen's test, preacher sign / prayer sign, limited joint mobility);
- 7-2: Contracture of pinky and/or ring finger (Dupuytren's contracture);
- 7-3: Locked finger, a.k.a. 'trigger finger' (stenosing tenosynovitis);
- 7-4: Numbness, tingling and/or pain (Carpal Tunnel Syndrome);



NOTICE: About 3% of the world population has diabetes mellitus, of which about 2.7% concerns Type 2 and 0.3% concerns Type 1. But in Down syndrome the occurence of diabetes type 1 is much higher (estimates indicate at least 4x times higher to up to 10%), therefore it is interesting to notice that 8 of the 26 hand markers in Down syndrome are also seen in the summary of hand markers for Diabetes Mellitus!

- MORE MULTI-PERSPECTIVE PALM READING -

The hand in RHEUMATOID ARTHRITIS
The hand in PSORIASIS
The hand in DOWN SYNDROME
The hand in FRAGILE-X SYNDROME

Fingernails problems in Diabetes Mellitus



THE FAMOUS 'SIMIAN LINE' (SINGLE PALMAR CREASE) IS ONLY A MINOR KEY-ELEMENT FOR THE HAND IN DIABETES MELLITUS (TYPE 2)


Hand Diagnostics:
the Simian Line & Diabetes Mellitus!

Various studies around the world have proven that the simian line is more often seen among diabetics than in the general population (about 3% of the healthy population has a simian line in at least one hand). This implicates that the simian line is much more important in the genetic syndromes (e.g. Down syndrome & Fragile-X syndrome) than in Diabetes Mellitus - but still, combined with other relevant hand markers the simian line can play a role in a hand diagnosis for Diabetes Mellitus.

This raises the question: 'how can the simian line serve as a diagnostic marker specific for Diabetes Mellitus?'

'Phantom picture' of the hand in Diabetes type 2.

Phantom picture for Diabetes Mellitus - type 2: including the simian line.

NOTICE: Later the author will present a comprehensive 'phantom picture' for the most typical hand-characteristics in Diabetes Mellitus.


HAND LINES & DIABETES MELLITUS:

• 1-1 - Apparent hand shape asymmetry
Prevalence:
- Diabetic patients: ? %; controls: ? %

LOG ODDS RATIO: ? (unknown)



FINGERNAILS & DIABETES MELLITUS:

• 2-1 - Fungal infection of the nail (onychomycosis)
Prevalence:
- Diabetic patients: 17-36 %; controls: 6.8-7.0 % 1

LOG ODDS RATIO: +1.57 (average)


• 2-2 - Redness in proximal nail fold (chronic paronychia)
Prevalence:
- Diabetic patients: 10.0 %; controls: +3.0 % 2

LOG ODDS RATIO: 1.28 (average)


• 2-3 - Half white, half pink nails (Terry's nails)
Prevalence:
- Diabetic type 2 patients: 10.0 %; controls: 0.5 % (rare in young people) 3

LOG ODDS RATIO type 2: +3.09 (average)


• 2-4 - Blue lunulae
Prevalence:
- Diabetic patients: ? %; controls: ? % 4

LOG ODDS RATIO: ? (unknown)


• 2-5 - Yellow nails + yellow skin
Prevalence:
- Diabetic patients: ? %; controls: ? %

LOG ODDS RATIO: ? (unknown)


• 2-6 - Spoon nail (koilonychia)
Prevalence:
- Diabetic patients: ? %; controls: ? %

LOG ODDS RATIO: ? (unknown)



FINGER LENGTH & DIABETES MELLITUS:

• 3-1 - High finger length asymmetry: e.g. 2D:4D asymmetry
Prevalence:
- Diabetic patients: ? %; controls: ? %

LOG ODDS RATIO: ? (unknown)



HAND LINES & DIABETES MELLITUS:

• 4-1 - Simian crease
Prevalence:
- Diabetic type 1 patients: males: 2.3-12.93 %, females: 1.0-12.0 %; controls: 0.3-2.0 % & 0.4-1.0 % 5-7
- Diabetic type 2 patients: males: 3.8-13.33 %, females: 0-14.23 %; controls: 0.3-2.0 % & 0.4-1.0 % 5-8


LOG ODDS RATIO type 1: +2.12 (average)
LOG ODDS RATIO type 2: +2.24 (average)


• 4-2 - Sydney line
Prevalence:
- Diabetic type 1 patients: males: 0.8, females: 4.0 %; controls: 3.8 % & 1.7 % 6
- Diabetic type 2 patients: males: 0, females: 7.6 %; controls: 3.8 % & 1.7 % 6


LOG ODDS RATIO type 1 (females only): +0.87
LOG ODDS RATIO type 2: +0.34 (average)


DERMATOGLYPHICS & DIABETES MELLITUS:

• 5-1 - Fingerprints: radial loop on ringfinger
Prevalence:
- Diabetic patients (confirmed by glucose tolerance test): 6.2 %; controls: 0.3 % 7

LOG ODDS RATIO: +3.09


• 5-2 - Fingerprints: radial loop on pinky
Prevalence:
- Diabetic patients (confirmed by glucose tolerance test): 2.3 %; controls: 0 % 7

LOG ODDS RATIO: +3.16


• 5-3 - Fingerprints: high thumb minus pinky ridge count (high MD15)
Prevalence:
- Diabetic type 2 patients: ? %; controls: ? %

LOG ODDS RATIO: ? (unknown)


• 5-4 - Palm: triradius c below ring finger is missing
Prevalence:
- Diabetic type 1 patients: 3.0-8.7 %; controls: 3.1-3.0 % 5-7
- Diabetic type 2 patients: 4.5-15.9 %; controls: 3.1-3.0 % 5-7

LOG ODDS RATIO type 1: +0.69 (average)
LOG ODDS RATIO type 2: +1.28 (average)


• 5-5 - Palm: ridge line C ends below ring finger (abbortive ridge line C)
Prevalence:
- Diabetic type 1 patients: 0.5-36.6 %; controls: 0.4-8.0 % 5-7
- Diabetic type 2 patients: 1.3-34.6 %; controls: 0.4-8.0 % 5-7

LOG ODDS RATIO type 1: +1.65 (average)
LOG ODDS RATIO type 2: +1.61 (average)


• 5-6 - Palm: a-b ridge count summarized for both hands < 70 (ridge count between triradius below index finger & triradius below middle finger)
Prevalence:
- Diabetic type 1 patients: ? %; controls: ? % 5,6,10
- Diabetic type 2 patients: ? %; controls: ? % 5,6,10

LOG ODDS RATIO type 1: ? (unknown)
LOG ODDS RATIO type 2: ? (unknown)


• 5-7 - Palm: 2 or 3 triradii on hypothenar
Prevalence:
- Diabetic type 1 patients: ? %; controls: ? % 5,6,10
- Diabetic type 2 patients: ? %; controls: ? % 5,6,10

LOG ODDS RATIO type 1: ? (unknown)
LOG ODDS RATIO type 2: ? (unknown)


• 5-8 - Palm: high positioned axial triradius
Prevalence:
- Diabetic type 1 patients: ? %; controls: ? % 5,6,10
- Diabetic type 2 patients: ? %; controls: ? % 5,6,10

LOG ODDS RATIO type 1: ? (unknown)
LOG ODDS RATIO type 2: ? (unknown)


• 5-9 - Palm: triradius t is missing
Prevalence:
- Diabetic type 1 patients: 0.75 %; controls: 0.5 % 5
- Diabetic type 2 patients: 3.95 %; controls: 0.5 % 5

LOG ODDS RATIO type 1: +0.41
LOG ODDS RATIO type 2: +2.10


• 5-10 - Palm: ulnar loop on hypothenar
Prevalence:
- Diabetic type 1 patients: 13.5 %; controls: 1.8 % 5
- Diabetic type 2 patients: 11.6 %; controls: 1.8 % 5

LOG ODDS RATIO type 1: +2.14
LOG ODDS RATIO type 2: +1.97


• 5-11 - Palm: radial arch on hypothenar
Prevalence:
- Diabetic type 1 patients: 5.6 %; controls: 0.5 % 5
- Diabetic type 2 patients: 4.7 %; controls: 0.5 % 5

LOG ODDS RATIO type 1: +2.47
LOG ODDS RATIO type 2: +2.28


• 5-12 - Palm: pattern in the hypothenar OR thenar of just one hand
Prevalence:
- Diabetic patients (confirmed by glucose tolerance test): 36.7 %; controls: 9.9 % 7

LOG ODDS RATIO: +1.67


• 5-13 - Palm: high density on thenar
Prevalence:
- Diabetic type 1 patients: 39.1 %; controls: 5.0 % 5
- Diabetic type 2 patients: 31.8 %; controls: 5.0 % 5

LOG ODDS RATIO type 1: +2.50
LOG ODDS RATIO type 2: +2.19



SKIN QUALITY & DIABETES MELLITUS:

• 6-1 - Thick, waxy/hardening skin on back of the hand (sclerodactyly)
Prevalence:
- Diabetic type 1 patients: 33 %; controls: 0.5 % (rare) 16,17

LOG ODDS RATIO type 1: +4.58


• 6-2 - Infections
Prevalence:
- Diabetic patients: ? %; controls: ? %

LOG ODDS RATIO: ? (unknown)


• 6-3 - Pink patches on back of the hand / fingers (granuloma annulare lesions)
Prevalence:
- Diabetic patients: 3 %; controls: 0.2 % 18

LOG ODDS RATIO: +2.73


• 6-4 - Little skin pebbles on back of the hand / fingers (Huntley's papules)
Prevalence:
- Diabetic patients: 72-75 %; controls: 12-21 % 15

LOG ODDS RATIO: +2.64


• 6-5 - Blisters (bullosis diabeticorum)
Prevalence:
- Diabetic patients: ? %; controls: ? % 14,18

LOG ODDS RATIO: ? (unknown)


• 6-6 - Shiny patches, first: red-brown & painless, later: yellow & ulceration (necrobiosis lipoidica)
Prevalence:
- Diabetic patients: 7 %; controls: 0.5 % (rare)

LOG ODDS RATIO: +2.71


• 6-7 - Dramatic appearing hand infections (e.g. Tropical Diabetic Hand Syndrome)
Prevalence:
- Diabetic patients: ? %; controls: ? %

LOG ODDS RATIO: ? (unknown)



MOTORICS & DIABETES MELLITUS:

• 7-1 - Neuropathy: loss of function: movement / sensation (Tinel's sign, Phalen's test, preacher sign / prayer sign, limited joint mobility)
Prevalence:
- Diabetic type 1 patients: 20-66 %; controls: 4 % 11,12,13
- Diabetic type 2 patients: 33-76 %; controls: 4 % 11,12,13

LOG ODDS RATIO type 1: +2.98 (average)
LOG ODDS RATIO type 2: +3.36 (average)


• 7-2 - Contracture of pinky and/or ring finger (Dupuytren's contracture)
Prevalence:
- Diabetic patients: 11-33 %; controls: 7 % 14

LOG ODDS RATIO: +1.31 (average)


• 7-3 - Locked finger, a.k.a. 'trigger finger' (stenosing tenosynovitis)
Prevalence:
- Diabetic patients: 20 %; controls: 2 % 14

LOG ODDS RATIO: +2.50


• 7-4 - Numbness, tingling and/or pain (Carpal Tunnel Syndrome)
Prevalence:
- Diabetic patients: 11-21 %; controls: 5 % 14

LOG ODDS RATIO: +1.28 (average)


(More details about prevalence of other significant hand markers for diabetes - plus the relates sources - will become available later)


SOURCES:

1)
The prevalence and management of onychomycosis in diabetic patients. A.K. Gupta et al., 2000

2) Infections and Diabetes: Mechanisms and Prospects for Prevention. P. Pozzilli & R.G.D. Leslie., 1994

3) Comparative study on secondary structural changes in diabetic and non-diabetic human finger nail specimen by using FTIR spectra. K.M. Farhan, 2010

4) Abnormalities of the lunula. M.E. Williams, 2009

5) Dermatoglyphics in diabetes mellitus of type 2 (T2DM) or non-insulindependent. A. Tarca, 2006

6) Digital and palmar dermatoglyphics in diabetes mellitus, multiple sclerosis and essential hypertension. G.F. Floris, et al., 2000

7) Association between diabetes mellitus and dermatoglyphics M.R. Chakravartti, 1967 (in: Hautleisten und Krankheiten - Hirsch, 1967)

8) Dermatoglphics study of 210 patients with diabetes mellitus. Li Yanhua Wu Shoushan Han Li Guo Qingmei He Liping, 1990

9) A fingerprint marker from early gestation associated with diabetes in middle age: The Dutch Hunger Winter Families Study. H.S. Kahn et al., 2008

10) Dermatoglyphics in Type 1 diabetes mellitus. A.G. Ziegler et al., 2009

11) Dupuytren's disease, carpal tunnel syndrome, trigger finger, and diabetes mellitus. M. Chammas et al., 1995

12) Reduced Prevalence of Limited Joint Mobility in Type 1 Diabetes in a U.K. Clinic Population Over a 20-Year Period. J.R. Lindsay et al., 2005

13) Limited joint mobility (LJM) of the hand in patients with diabetes mellitus: relation to chronic complications. H.S. Starkman et al, 1986

14) Hand manifestations of diabetes mellitus. P.G. Fitzgibbons & A-P C. Weiss, 1995

15) Finger pebbles: a dermatologic sign of diabetes mellitus. D.S. Hollister et al., 2000

16) Updates in the Management of Cutaneous Manifestations of Diabetes Mellitus. A.S. Hayat et al., 2010

17) Scleredema and diabetic sclerodactyly. Lisa Moed Gruson & Andrew Franks, 2005

18) Localized granuloma annulare is associated with insulin-dependent diabetes mellitus. M.F. Muhlemann & D.R.R. Williams, 2006

 


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