Hand chart for the Big Five personality dimension Conscientiousness (2016) Hand chart for the Big Five personality dimension Extraversion (2016) Hand chart for the Big Five personality dimension Neuroticism (2016) Hand chart for hypercalcemia (1971) Hand chart for arthrogryposis (1981) Hand chart for cri-du-chat syndrome - Hautleistenfibel (1981) Hand chart for Down syndrome (2011) Hand chart for Edwards syndrome (1981) Hand chart for fragile-X syndrome (2014) Hand chart for Holt-Oram syndrome (1981) Hand chart for Kabuki syndrome (A. Chudley) Hand chart for Klinefelter syndrome (A. Rodewald & H. Zankl, 1981) Hand chart for Cornelia de Lange syndrome (A. Rodewald & H. Zankl, 1981) Hand chart for Patau syndrome (1981) Hand chart for Prader-Willi syndrome (1971) Hand chart for rubella syndrome (1971) Hand chart for Smith-Lemli-Opitz syndrome (1971) Hand chart for Turner syndrome - Hautleistenfibel (1981) Hand chart for Williams syndrome (R. Rodewald, 1994) Hand chart for Wolf-Hirschhorn syndrome (B. Schaumann & M. Alter, 1976) Hand chart for XXYY syndrome (1971) Hand chart for XYY syndrome (1971) Hand chart for 18p- syndrome, a.ka. de Grouchy syndrome 1 (1981)

- Some of the available hand charts are displayed above - you can use the displayed pictures above for browsing -


Publication: november 21, 2015

Hand Charts for Holt-Oram Syndrome!

Holt-Oram syndrome - a.k.a. heart-hand syndrome - is an autosomal dominant disorder that affects bones in the arms and hands - typical malformations in the hands are: a missing thumb or a long thumb featured with 3 phalanges creating the looks of a finger instead of a thumb. About 75 percent of individuals with Holt-Oram syndrome have heart problems.

Prevalence: estimated at 1 in 100,000 live births.

One hand chart is available for Holt-Oram syndrome describing the significance of various typical features inside especially the dermatoglyphics, which manifest often combined with a simian line and/or a malformed life line [thenar crease] - see picture below.


NOTICE: Individual hand features described below should not get associated in isolation with any theme; only combinations involving multiple hand levels have potential for diagnostic purposes.

Hand chart for Holt-Oram syndrome - Hautleistenfibel (1981).
Hand chart source:
Hautleistenfibel (1981), p.117;
authors: A. Rodewald & H. Zankl




Other significant hand signs (not reported inside the hand charts):

Clinodactyly & brachydactyly belong to the cardinal manifestations of HOS.

But one of the most characteristic findings in the Holt-Oram syndrome (HOS) concerns a thumb anomaly; the thumbs may manifest absent [thumb aplasia] (35% - see photo 1st below), underdeveloped [thumb hypoplasia], or they may manifest as a triphalangeal, nonopposable, finger-like digit [first-web syndactyly] (19% - see 2nd photo below). Duplication of the thumb [a.k.a. preaxial polydactyly, split thumb] is also a possibility.

Thumb anomaly in Holt-Oram syndrome manifesting as absence of thumb.
Thumb anomaly in Holt-Oram syndrome manifesting as absence of thumb.


Thumb anomaly in Holt-Oram syndrome manifesting as a (nonopposable) finger-like digit.
Thumb anomaly in Holt-Oram syndrome manifesting as
a (nonopposable) finger-like digit.


All significant hand signs listed above for cri-du-chat syndrome together cover four out of the nine perspectives of the hand as defined according Multi-Perspective Hand Reading (including hand level 2, 5, 8 & 9).

A summary of the most significant hand sign combinations in Holt-Oram syndrome is described here:

Decoding the language of the hand:
hand sign combinations in Holt-Oram syndrome!





Hand charts are available for many other diagnostic issues;
start browsing HERE


Martijn van Mensvoort - Hand Research

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